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S‐Adenosylmethionine (SAM) is one of the most common co‐substrates in enzyme‐catalyzed methylation reactions. Most SAM‐dependent reactions proceed through an SN2 mechanism, whereas a subset of them involves radical intermediates for methylating non‐nucleophilic substrates. Herein, we report the characterization and mechanistic investigation of NosN, a class C radical SAM methyltransferase involved...
Ein kräftiges Methylierungsmittel:Im Unterschied zu allen anderen bekannten S‐Adenosylmethionin(SAM)‐abhängigen Methyltransferasen produziert das Enzym NosN nicht S‐Adenosylhomocystein (SAH) als Koppelprodukt, wie Q. Zhang und Mitarbeiter in ihrer Zuschrift auf S. 3915 ff. nachweisen. Stattdessen wandelt NosN als direkter Methyldonor SAM über einen radikalischen Methylierungsmechanismus in 5′‐Methylthioadenosin...
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