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Sericin‐wrapped mesoporous silica nanoparticles (SMSNs) with pH and protease dual responsiveness are successfully fabricated as a lysosome‐targeting drug delivery system by Guobin Wang, Lin Wang, Zheng Wang, and co‐workers in article number 1602567. Such a dual responsive system offers a rapid doxorubicin release in lysosomes, which bypasses the membrane pump mediated drug efflux, thereby achieving...
Multidrug resistance (MDR) and adverse side effects are the major challenges facing cancer chemotherapy. Here, pH/protease dually responsive, sericin‐coated mesoporous silica nanoparticles (SMSNs) for lysosomal delivery of doxorubicin (DOX) to overcome MDR and reduce systemic toxicity are reported. Sericin, a natural protein from silkworm cocoons, is coated onto MSNs as a gatekeeper via pH sensitive...
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