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Background
In preclinical models of prostate cancer (PC), disulfiram (DSF) reduced tumor growth only when co‐administered with copper (Cu), and Cu uptake in tumors is partially regulated by androgen‐receptor signaling. However, prior trials of DSF in PC used DSF as monotherapy.
Objective
To assess the safety and efficacy of concurrent administration of DSF with Cu, we conducted a phase 1b clinical...