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The aim of the study was to explore the factors in inadequate‐responders to treatment with adefovir (ADV) with or without genotypic resistance. The reverse‐transcriptase (RT) gene of hepatitis B virus (HBV) was sequenced in 161 patients with inadequate‐response to ADV and analyzed for HBV genotypes using a phylogenetic approach. Seventy‐six patients (47.2%) were found to carry the rtA181V/T/S or rtN236T...
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