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This study compares the predicted metabolic capabilities of seven sequenced bacterial strains within the family Vibrionaceae, with emphasis on the possible biosynthetic pathways encoded by their genomes. The goal is to elucidate whether the high diversity among Vibrionaceae in terms of environment and pathogenicity is reflected in their suite of available metabolic processes. The data set included...
We examined the metabolic capabilities of eight Escherichia coli strains in order to identify variations among these strains which might account for their alternate mechanisms of infection or levels of virulence. Our data set included two non-pathogenic strains, two diarrheagenic strains and four extra-intestinal pathogenic strains. The metabolic pathway complements of these strains were deduced using...
Pathway-genome databases were constructed for three Yersinia pestis strains and a single Yersinia pseudotuberculosis strain in order to compare their predicted metabolic pathways. Y. pestis, the causative agent of bubonic plague, is 100% host-associated while Y. pseudotuberculosis is a free-living aquatic organism which is believed to be ancestral to Y. pestis. A total of 326 pathways were identified...
We conducted gene expression profiling and pathway analysis of microarray data generated from a gefitinib versus M4-AML study. Our findings indicate that a therapeutic reduction of the human v-Myc oncoprotein correlated to molecular reversal of cell transformation within 24 hours of treatment. We analyzed the known efficacies of gefitinib and were able to identify bona fide gefitinib targets in the...
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