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The development of bioorthogonal activation in drug release represents a promising avenue for precise and safe anticancer treatment. However, two significant limitations currently hinder their clinical application: i) the necessity for separate administration of the drug precursor and its corresponding activator, leading to poor drug accumulation and potential side effects; ii) the reliance on exogenous...
The aim of this work is to develop an environmentally friendly, safe, and simple route for realizing efficient preparation of aspirin. Here, inspired by enzyme synthesis in vivo, the aspirin synthesis has been realized by sub‐nanoconfined esterification with directional flow and ≈100% conversion in an unprecedented reaction time of <6.36 s at 23 °C. Such flow esterification reaction is catalyzed...