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Markowitz’s modern portfolio theory is one of the major milestones in finance. However, the empirical performance of the resulting optimal portfolio has received much criticism by many researchers. Bai et al. (Math Finance 19(4):639–667, 2009a) proved that the estimated optimal portfolio always overestimates the expected return, particularly when the portfolio consists of a large number of assets...
In microarray experiments, expression profiles are obtained for thousands of genes under several treatments. Traditionally, most of the statistical techniques employed are concentrated around univariate methods. They ignore the inter-gene dependence and do not use any prior biological knowledge. Gene set analysis addresses both these concerns by analyzing together a group of correlated genes, for...
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