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The development of cerium (Ce) single‐atom (SA) electrocatalysts for oxygen reduction reaction (ORR) with high active‐site utilization and intrinsic activity has become popular recently but remains challenging. Inspired by an interesting phenomenon that pore‐coupling with single‐metal cerium sites can accelerate the electron transfer predicted by density functional theory calculations, here, a facile...
The poor oxygen diffusion and sluggish oxygen reduction reaction (ORR) kinetics at multiphase interfaces in the cathode suppress the practical application of zinc‐air batteries. Developing effective strategies to tackle the issue is of great significance for overcoming the performance bottleneck but remains challenging. Here, a multiscale hydrophobic surface is designed on the iron single‐atom catalyst...
Nanotheranostics have been actively sought in precision nanomedicine in recent years. However, insufficient tumor accumulation and limited cell uptake often impede the nanotheranostic efficacy. Herein, pH‐sensitive charge‐reversible polymer‐coated layered double hydroxide (LDH) nanohybrids are devised to possess long circulation in blood but reserve surface charges in the weakly acidic tumor tissue...
Cancer immunotherapy is a promising cancer terminator by directing the patient's own immune system in the fight against this challenging disorder. Despite the monumental therapeutic potential of several immunotherapy strategies in clinical applications, the efficacious responses of a wide range of immunotherapeutic agents are limited in virtue of their inadequate accumulation in the tumor tissue and...
Multidrug resistance (MDR), is the key reason accounting for the failure of cancer chemotherapy, remains a dramatic challenge for cancer therapy. In this study, the one‐step microfluidic fabrication of a rigid pH‐sensitive micellar nanocomplex (RPN) with tunable rigidity and acid‐switchable surface charge for overcoming MDR by enhancing cellular uptake and lysosome escape is demonstrated. The RPN...
In article number 1603109, Jiashu Sun, Haijun Yu, Xingyu Jiang, and co‐workers utilize microfluidic chips to generate rigid pH‐sensitive micellar nanocomplex (RPN) with tunable rigidity and acid‐switchable surface charge for overcoming cancer drug resistance. The functionalization of RPN is realized through the incorporation of rigid PLGA core into pH‐sensitive micelle. The RPN significantly enhances...
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