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Background: Disruption of cellular metabolite levels can adversely impact development. Specifically, loss‐of‐function of the C. elegans NAD+ salvage biosynthesis gene PNC‐1 results in an array of developmental phenotypes. Intriguingly, PNC‐1 and its functional equivalent in vertebrates are secreted, but the contributions of the extracellular enzymes are poorly understood. We sought to study the tissue‐specific...
Salvage biosynthesis of nicotinamide adenine dinucleotide (NAD + ) from nicotinamide (NAM) lowers NAM levels and replenishes the critical molecule NAD + after it is hydrolyzed. This pathway is emerging as a regulator of multiple biological processes. Here we probe the contribution of the NAM-NAD + salvage pathway to muscle development and function using Caenorhabditis elegans...
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