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α1 Nicotinic acetylcholine receptor (α1nAChR) is an important nicotine receptor that is widely distributed in vascular smooth muscle cells, macrophages, and endothelial cells. However, the role of α1nAChR in nicotine‐mediated atherosclerosis remains unclear. The administration of nicotine for 12 weeks increased the area of the atherosclerotic lesion, the number of macrophages infiltrating the plaques,...
OBJECTIVESuccess in clinical trials of intracranial atherosclerosis (ICAS) is related to accurate identification of high‐risk patients. Noninvasive computational fluid dynamics (CFD) of stenotic lesions may enhance therapeutic decision‐making. We determined whether physiologic parameters change downstream cerebral hemodynamics in patients with ICAS.
METHODSConsecutive ICAS patients who underwent...
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