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DNA-binding proteins play a pivotal role in various intra- and extra-cellular activities ranging from DNA replication to gene expression control. With the rapid development of next generation of sequencing technique, the number of protein sequences is unprecedentedly increasing. Thus it is necessary to develop computational methods to identify the DNA-binding proteins only based on the protein sequence...
A fundamental problem for software testing is the oracle problem, which means that in many practical situations, it is extremely expensive, if not impossible, to verify the test result given any possible program input. Metamorphic testing is an approach to alleviating the oracle problem. The key part of metamorphic testing is a set of necessary properties of the software under test, namely metamorphic...
Posttranslational modifications mediate important regulatory functions in biology. The acetylation of the p53 transcription factor, for example, promotes transcriptional activation of target genes including p21. Here we show that the acetylation of two lysine residues in p53 promotes recruitment of the TFIID subunit TAF1 to the p21 promoter through its bromodomains. UV irradiation of cells diacetylates...
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