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Multidrug resistance (MDR) is an issue that is not only related to cancer cells but also associated with the tumor microenvironments. MDR involves the complicated cancer cellular events and the crosstalk between cancer cells and their surroundings. Ideally, an effective system against MDR cancer should take dual action on both cancer cells and tumor microenvironments. The authors find that both the...
A complicated mechanistic interaction exists between cancer cells and tumor microenvironments. In article number 1700403, Yongzhuo Huang and co‐workers describe a “one‐stone‐two‐birds” strategy, which uses a mannosylated albumin nanoparticulate co‐delivery system to dual‐target cancer cells and M2 macrophages via the pathways of both mannose receptors and the albumin‐binding protein SPARC. This results...
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