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We report herein the synthesis and structure–activity relationships (SAR) of a series of benzyl ether compounds as an S1P 1 receptor modulator. From our SAR studies, the installation of substituents onto the central benzene ring of 2a was revealed to potently influence the S1P 1 and S1P 3 agonistic activities, in particular, an ethyl group on the 2-position afforded satisfactory...
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