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Mice that lack the guanine nucleotide exchange factor (GEF) Vav1 exhibit particular defects in antigen-triggered T cell activation but may have an autoreactive T cell repertoire due to impaired intra-thymic negative selection. MOG 35-55 -induced experimental autoimmune encephalomyelitis (EAE) was used to test the susceptibility of Vav1 -/- mice to organ-specific...
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