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Surface modification with bioactive agents capable of combating thrombosis is a widely used strategy for developing antithrombotic biomaterials. However, exposure of the blood to the antithrombotic agent on the material surface may cause hemostatic disorders under normal conditions. Ideally an implanted biomaterial should respond appropriately on demand to a specific change in the physiologic environment,...
In article number 1703934, Dan Li, Hong Chen, and co‐workers report a novel thrombolytic coating whose activity is triggered by thrombosis. The coated surfaces remain inert in normal plasma environment while releasing tissue plasminogen activator (t‐PA) and promoting fibrinolysis in response to thrombin. Such coating could avoid unfavorable complications caused by continuous release of antithrombotic...
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