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The phosphatidylinositol-3-kinase (PI3-K) pathway has been suggested to play a pivotal role in neuronal survival. Although PI3-K has been recently identified as a neuroprotectant, there are no reports regarding the effect of a direct PI3-K activator on Aβ-induced neurotoxicity. We investigated whether direct PI3-K activation prevents Aβ-induced neurotoxicity. To evaluate the effect of Aβ on neuronal...
Deposition of amyloid-β protein (Aβ) is one of the most important pathologic features in Alzheimer's disease. It is well known that Aβ induces neuronal cell death through several pathogenic mechanisms. Although the role of glycogen synthase kinase (GSK)-3β in the neurotoxicity of Aβ has been highlighted, there has been no report evaluating the effect of direct GSK-3β inhibition on Aβ-induced neurotoxicity...
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