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Understanding the direct interaction of nanostructures per se with biological systems is important for biomedical applications. However, whether nanostructures regulate biological systems by targeting specific cellular proteins remains largely unknown. In the present work, self‐assembling nanomicelles are constructed using small‐molecule oleanolic acid (OA) as a molecular template. Unexpectedly, without...
Cancer Cell Pyroptosis
In article number 2205531, Ke‐Wu Zeng and co‐workers describe the natural product oleanolic acid‐based self‐assembling nanostructures specially bind to proteasome subunit alpha 6 (PSMA6) to activate proteasome for cancer cell pyroptosis. This study opens up a new direction for the development anti‐cancer nanomedicine from natural resources.
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