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Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal injury is essential. Our study aimed to explore possible mechanisms of PMB‐induced nephrotoxicity in vivo and in vitro. Mice were treated...
Objectives
Periodontitis is closely associated with kidney disease and reactive oxygen species (ROS) involvement. Mitochondria are the primary source of both endogenous ROS and renal energy. We investigated whether resveratrol (RSV) prevents renal injury and mitochondrial dysfunction in periodontitis rats.
Methods
Thirty male Wistar rats were divided into control, experimental periodontitis (Ep)...