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Constitutive and PKC-regulated α-secretase pathways have been reported to produce the secreted form of α-secretase-derived APP (sAPPα). Here, we examined putative role of furin in the regulation of α-secretase activity in vitro and in vivo. Overexpression of the prodomain of furin and infection with a furin-specific inhibitor significantly reduced the levels of sAPPα regardless of PKC activity, whereas...
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