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The complexation of trimethoprim (TMP) with β-cyclodextrin (β-CD) was studied. UV-spectrophotometry and phase-solubility techniques were employed to investigate the complexation behaviour in liquid medium, and to demonstrate that the aqueous solubility of TMP increased 2.2-fold due to complexation with β-CD. Solid samples prepared by co-evaporation (in 2wt% acetic acid solution) have also been studied,...
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