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Gerichtete Evolution Im Forschungsartikel auf S. 23865 nutzen Benoit Roux, Jared C. Lewis et al. gerichtete Evolution zur Verbesserung der Ausbeute und Selektivität von Dirhodium‐katalysierten Diazo‐Kreuzkupplungen mit künstlichen Metalloenzymen.
Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross‐coupling to form an alkene that, in a one‐pot cascade reaction, is reduced to an alkane with high enantioselectivity (typically >99 % ee) by an alkene reductase. The numerous...