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The Sonic Hedgehog (Shh) pathway affects cancer initiation, progression, and metastasis, but its role in papillary thyroid carcinoma (PTC) remains elusive. To characterize expression and clinical significance of Shh and the transcription factor Gli-1—the key elements of the Shh pathway in PTC tissues—we immunohistochemically examined Shh/Gli-1 expression in PTC tissues from 142 patients, along with...
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