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Modern biotechnologies enable the production of chemicals using engineered microorganisms. However, the cost of downstream recovery and purification steps is high, which means that the feasibility of bio-based chemicals production depends heavily on the synthesis of cost-effective separation networks. To this end, we develop a superstructure-based framework for bio-separation network synthesis. Based...
In principle, optimization‐based “superstructure” methods for process synthesis can be more powerful than sequential‐conceptual methods as they account for all complex interactions between design decisions. However, these methods have not been widely adopted because they lead to mixed‐integer nonlinear programs that are hard to solve, especially when realistic unit operation models are used. To address...
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