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Retinopathy of prematurity is a vision‐threatening disease associated with retinal hypoxia‐ischemia, leading to the death of retinal neurons and chronic neuronal degeneration. During this study, we used the oxygen‐induced retinopathy mice model to mimic retinal hypoxia‐ischemia phenotypes to investigate further the neuroprotective effect of melatonin on neonatal retinal neurons. Melatonin helped maintain...
Madecassic acid (MA) is an abundant triterpenoid in Centella asiatica (L.) Urban. (Apiaceae) that has been used as a wound-healing, anti-inflammatory and anti-cancer agent. Up to now, the effects of MA against oxidative stress remain unclear. In this study, we investigated the effect of MA and its mechanisms on hypoxia-induced human Retinal Microvascular Endothelial Cells (hRMECs). hRMECs were pre-treated...
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