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Olanzapine and its precursor desmethyl-Olanzapine were synthesized from malononitrile, propionaldehyde, 1-fluoro-2-nitrobenzene, and substituted piperazine in 4, 4, 5, and 5 steps with 35%, 32%, 26%, and 32% overall chemical yield, respectively. [ 11 C]Olanzapine was prepared from desmethyl-Olanzapine with [ 11 C]CH 3 OTf through N-[ 11 C]methylation and isolated by...
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