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We prepared PEI-As2O3/Mn0.5Zn0.5Fe2O4 magnetic complex as drug and pHsp-HSV-TK gene vector, at the same time it could induce the gene expressed by heat. Then the MTT assay, hemolysis test, the mouse of LD50 test and micronucleus (MN) test were presented to evaluate the toxicity of it in vitro and in vivo . The therapeutic effects on cultured HepG2 cells treated by thermochemotherapy and pHsp70-HSV-TK...
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