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Dissolving Microneedles
In article number 2309920, Shayan Fakhraei Lahiji, Yong‐Hee Kim, and co‐workers present a hyaluronic acid‐based microneedle patch (MicroLock) for obesity treatment. This self‐locking patch delivers FABPs‐silencing shRNA directly to adipocytes, effectively reducing body weight and improving insulin resistance. This novel transdermal platform showcases significant potential for...
Advancements in gene delivery systems are pivotal for gene‐based therapeutics in oncological, inflammatory, and infectious diseases. This study delineates the design of a self‐assembled oligopeptoplex (SA‐OP) optimized for shRNA delivery to adipocytes, targeting obesity and associated metabolic syndromes. Conventional systems face challenges, including instability due to electrostatic interactions...
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