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Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by enhancing the autophagy of microglia to phagocytose and degrade α‐syn via controlled opening of their surface TRPV1 channels with rationally designed photothermal nanoagent is reported. The Cu2−xSe‐anti‐TRPV1 nanoparticles...
Microglial Autophagy
In article number 2108435, Zhen Li and co‐workers report that Cu2−xSe‐anti‐TRPV1 nanoparticles can efficiently target the TRPV1 channels on the membrane of microglia, and photothermally activate them under second near‐infrared laser irradiation to allow the efficient influx of calcium ions, which boosts the autophagy of microglia for clearance of α‐synuclein aggregates to improve...
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