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Under acidic conditions, indole-3-carbinol (I3C) is converted to a series of oligomeric products thought to be responsible for the biological effects of dietary I3C. Chromatographic separation of the crude acid mixture of I3C, guided by cell proliferation assay in human MCF-7 cells, resulted in the isolation of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane (LTr-1) as a major antiproliferative component...
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