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A new single labelled DNAzyme sensor was developed for trace UO22+ detection based on the fact that the four consecutive guanines at the 5′-end of DNAzyme quenches the fluorescence of fluophor-tetramethyl-6-carboxyrhodamine (TAMRA) modified at the 3′-end of substrate. When UO22+ coexisted with DNAzyme sensor, UO22+ catalyzed the phosphoester cleavage reaction at the rA position of the substrate accompanied...
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