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Inside Front Cover: Designed for local application to exposed tissues, a synthetic lysine‐leucine biopolymer, K100L40, provides a combination of direct microbicidal activity and barrier properties. These amino acid block copolymers are active against Gram‐positive and Gram‐negative bacteria, as well as yeast. Driven by association of water insoluble leucine segments, they form viscous solutions and...
Antimicrobial properties of a long‐chain, synthetic, cationic, and hydrophobic amino acid block copolymer are reported. In 5 and 60 min time‐kill assays, solutions of K100L40 block copolymers (poly(l‐lysine·hydrochloride)100‐b‐poly(l‐leucine)40) at concentrations of 10–100 µg mL−1 show multi‐log reductions in colony forming units of Gram‐positive and Gram‐negative bacteria, as well as yeast, including...
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