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For enhanced COVID‐19 vaccines, in article number 2004210, Yufei Xia, Guanghui Ma, and co‐workers pack licensed alum on a squalene/water interphase. Thereby, this century‐old adjuvant “travels through time” in a new form of alum‐stabilized Pickering emulsion (PAPE), which not only inherits the clinically acknowledged biosafety, but also demonstrates enhanced cellular uptake and cross‐presentation...
For rapid response against the prevailing COVID‐19 (coronavirus disease 19), it is a global imperative to exploit the immunogenicity of existing formulations for safe and efficient vaccines. As the most accessible adjuvant, aluminum hydroxide (alum) is still the sole employed adjuvant in most countries. However, alum tends to attach on the membrane rather than entering the dendritic cells (DCs), leading...
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