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Abstract: Acetaminophen has been used as an analgesic for more than a hundred years, but its mechanism of action has remained elusive. Recently, it has been shown that acetaminophen produces analgesia by the activation of the brain endocannabinoid receptor CB1 through its para‐aminophenol (p‐aminophenol) metabolite. The objective of this study was to determine whether p‐aminophenol could be toxic...
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