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T helper cells, especially Th1 and Th17 cells, were reported to play a pivotal role in the pathogenesis of inflammatory bowel disease (IBD). However, the underlying factors regulating T cell functions in IBD progression remain to be fully elucidated. Here, we revealed that IL‐17RD/Sef exacerbates DSS‐induced colitis by regulating the balance of T cell subsets and their secretion of associated cytokines...