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It has been suggested that hepatocyte growth factor (HGF) and insulin-like growth factor binding protein (IGFBP)-3 are associated with gefitinib resistance in non-small cell lung cancer (NSCLC). We investigated the predictive and prognostic roles of these proteins in NSCLC patients treated with gefitinib.Of 106 patients enrolled in a randomized phase II study of gefitinib, 97 had plasma samples available...
Oh JE, An CH, Yoo NJ, Lee SH. Detection of low‐level EGFR T790M mutation in lung cancer tissues. APMIS 2011; 119: 403–11.
Epidermal growth factor receptor (EGFR) gene mutation status is critical to predicting responsiveness to EGFR tyrosine kinase inhibitor (TKI) therapies in non‐small cell lung cancer (NSCLC) patients. However, a vast majority of the patients experience recurrence of the cancers...
Both epidermal growth factor receptor (EGFR) and RAS gene mutations contribute to the development of non-small cell lung cancer (NSCLC). Because RAS is one of the downstream molecules in the EGFR signal transduction, the association between the somatic mutations of EGFR and RAS may be important in the pathogenesis of NSCLC . However, to date, such data are lacking. In this study, we analyzed the hotspot...
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