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Rosbin (Thieno [2, 3‐c] piperidine‐3‐carboxamide‐2‐[(3‐methoxy‐naphtha‐lene‐2‐carbonyl)‐amino]‐6‐(benzyl)‐, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non‐small cell lung cancer A549 cells with an IC50 of 2.05 ± 0.31 µM. It only decreases growth of non‐tumour MRC‐5 cells at the doses higher...
Chemical screening using synthetic small molecule libraries has provided a huge amount of novel active molecules. It generates lead compound for drug development and brings focus on molecules for mechanistic investigations on many otherwise intangible biological processes. In this study, using non‐small cell lung cancer cell A549 to screen against a structurally novel and diverse synthetic small molecule...
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