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Abstract. Bioactivity of many peptides depends upon post-translational -amidation of inactive precursors by two enzyme activities known collectively as peptidylglycine -amidating monooxygenase (PAM). PAM enzymes are particularly abundant in the pituitary. The distribution of PAM immunoreactivity and messenger ribonucleic acid (mRNA) in the adult human pituitary and in pituitary tumours was investigated...
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