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DNA copy number changes represent molecular fingerprints of solid tumors and are as such relevant for better understanding of tumor development and progression. In this study, we applied genome-wide array comparative genomic hybridization (aCGH) to identify gene-specific DNA copy number changes in chromosomal (CIN)- and microsatellite (MIN)-unstable sporadic colorectal cancers (sCRC). Genomic DNA...
Aims Numerical and structural centrosome changes have been described for and linked with genetic instability in solid tumors. Here, we specifically address centrosome aberrations in the adenoma–carcinoma sequence of colorectal cancer by detailed evaluation of γ-tubulin staining patterns. Methods Formalin-fixed and paraffin-embedded specimens (normal colonic epithelium n=21; low-grade intraepithelial...
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