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Nuclear factor-κB (NF-κB) is a transcription factor that plays crucial roles in inflammation and immunity. Understanding the positive and negative regulation of NF-κB activity is therefore of fundamental importance. A few previous studies reported that inhibition of the phosphatidylinositol 3-kinase (PI3K)–Akt pathway enhances lipopolysaccharide (LPS)-induced activation of NF-κB. However, many aspects...
The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated. Complete inhibition of interleukin (IL)-1β-induced Akt phosphorylation occurred at 50 μM LY29 or 100 nM WM. At these concentrations, LY29, but not WM, significantly inhibited constitutive...
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