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The generation and maintenance of B lymphocytes is controlled by biochemical signals tramsitted by the B cell antigen receptor (BCR) complex. These signals are transduced by multiple cytoplasmic protein tyrosine kinases (PTKs) including Lyn, Syk, and Bruton's tyrosine kinase (BTK). Upon BCR engagement, these PTKs activate downstream effectors, including transcription factors that modulate gene expression...
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