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There is an urgent need for animal models of coronavirus disease 2019 to study immunopathogenesis and test therapeutic intervenes. In this study, we showed that NOD/SCID IL2rg–/– (NSG) mice engrafted with human lung (HL) tissue (NSG‐L mice) could be infected efficiently by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and that live virus capable of infecting Vero cells was found in...