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Familial combined hyperlipidemia (FCHL) is a genetic disorder of lipid metabolism associated with insulin resistance and abnormalities in fatty acid metabolism whose underlying mechanisms are largely unknown. Perturbations in the TNFα/TNF-R pathway may play a role in these abnormalities.We determined plasma levels of TNFα and sTNF-R p75 in 85 FCHL patients (TC 245±45 mg/dl; TG 260±148 mg/dl; apoB...
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