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Weedy rice refers to the unwanted plants of the genus Oryza that have some undesirable agronomic traits and pose a major threat to sustainable rice production worldwide. Widespread adoption of direct seeded rice and hybridization or gene flow between cultivated rice and their wild relatives has resulted in the creation and dissemination of weedy rice. Currently, weedy rice (Oryza sativa f. spontanea...
Optical trap provides a new and unique tool for manipulation in micro/nano scale and have wide applications in biological fields. Increasing demands for both accuracy and efficiency in cell manipulation highlight the need for automation process that integrates robotics and optical tweezers technologies. A clear understanding of the forces exerted on cells, i.e., trapping and viscous drag forces, is...
Over the past decade, the rapid development of biotechnologies such as gene injection, in-vitro fertilization, intracytoplasmic sperm injection (ICSI) and drug development have led to great demand for highly automated high precision equipment for microinjection. Recently a new cell injection technology using piezo-driven pipettes with a very small mercury column was invented and successfully applied...
Mechanical properties of biological cells play an important role in regulating cellular functions. Some micromanipulation methods have been reported in the literature to measure cell mechanics, but they are either high-costly or difficultly-operated. This paper presents our approach to use microrobotic cell injection technology as the test bed to characterize the mechanical properties of biological...
In a robotic cell injection system, the penetration force applied on the cell reflects the changes of the physical behavior of the cell. The force, if not controlled properly, may damage to the cells or even lead to death of the cells. The current cellular force measurement is limited by the inherent cantilever structure of the sensor, which may not be applicable to a practical cell injection system...
Biological cell injection is laborious work which requires lengthy training and suffers from a low success rate. Although the development of biomanipulation technology has enabled steps towards automation of adherent cell injection, the automation of suspended cell injection remains a significant challenge. In this paper, a prototype cell injection system for automatic batch injection of suspended...
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