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This study investigated risk assessment and anxiolytic/anxiogenic drug effects in “low brain angiotensinogen” transgenic rats (TGR) in comparison to wild-type Sprague–Dawley rats (SD) in the canopy test of anxiety-related behaviour.TGR showed a higher frequency of the risk assessment behaviour as indicated by performance of stretched attend posture (SAP) compared to SD. Diazepam (0.25mg/kg) reduced...
The first model of genetically engineered hypertension, the transgenic rat TGR (mREN2)27, provides a unique opportunity to study the behavioural effects of an altered brain renin-angiotensin system. The TGR (mREN2)27 rats, characterised by fulminant hypertension, show differences in both the peripheral and central angiotensin systems. The behaviour of male transgenic TGR (mREN2)27 and male Sprague-Dawley...
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