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The purpose of the study was to compare the bone anabolic effects of basic fibroblast growth factor (bFGF) at hematopoietic (red) and fatty (yellow) marrow sites in ovariectomized (ovx) rats. Female Sprague Dawley rats were subjected to ovariectomy or sham surgery at 3 months of age and maintained untreated for 2 months after surgery. Three groups of ovx rats were then injected intravenously with...
The main goal of this study was to determine whether vertebral cancellous wall width changes with age and parathyroid hormone (PTH) treatment in rats. Female Sprague-Dawley rats were subjected to sham surgery or ovariectomy at 3 months of age. One month after surgery, ovariectomized (ovx) rats were injected subcutaneously (s.c.) 5 days/week for 6 weeks with vehicle or human parathyroid hormone [hPTH...
The purpose of the current report is to compare the skeletal effects of PTH treatment at red (hematopoietic) and yellow (fatty) marrow sites in ovariectomized (ovx) rats. In the first study, mature, slowly growing ovx rats that were 4 months of age and 4 weeks postovariectomy were treated with human parathyroid hormone [hPTH(1-34)] (80 μg/kg, 5 days/week) for 6 weeks. In the second study, aged ovx...
In the ovariectomized (ovx) rat, the nonsteroidal antiestrogens, clomiphene (CLO) and tamoxifen (TAM), at dose levels that prevent development of osteopenia to a degree approaching that of 17β-estradiol are, in contrast to 17β-estradiol, only weakly uterotrophic. Metabolites of CLO and TAM might contribute differentially to these effects. Thus, we have evaluated bone protective and uterine effects...
Effects of intermittent prostaglandin E2 (PGE2) alone, or PGE2 plus risedronate (Ris) and daily PGE2 treatments on the distal tibia, a non-growing cancellous bone site with its structure similar to that human, were studied in ovariectomized (ovx) rats. Six month old rats were treated immediately after ovx with either two cycles of 60-day each of alternating on and off PGE2 (6 mg/kg/d) and Ris (5μg/kg/2x/wk)...
Effects of risedronate and prostaglandin E 2 (PGE 2 ) alone or in combination on the distal tibia, a non-growing bone site with closed epiphysis at 3 months of age, were studied in ovariectomized (ovx) rats. Six-month-old Sprague-Dawley female rats were either ovx or sham-ovx. Rats were treated immediately after operation either with risedronate (5 μg/kg/2x/wk), PGE 2 (6 mg/kg/d),...
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