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Atrial septal defect (ASD) is a common cardiovascular malformation and an important contributor to substantial morbidity and mortality. Increasing evidence demonstrates that mutated NKX2-5, a gene encoding a homeobox transcription factor crucial to cardiogenesis, is a significant genetic determinant for congenital ASD. Nevertheless, the genetic basis for ASD in a majority of ASD patients remains largely...
We here analyzed the correlation between the genic GC content and the temperature range conditions of prokaryotes. To identify those genes whose surrounding GC levels exhibit patterns different for organisms under different temperature conditions but transcending phylogenetic boundaries, we first focused on the complete list of organisms, then partial lists of organisms with one phylum being excluded,...
Rapid and accurate identification of potentially interested pathways through the analysis of genome-wide expression profiles remains an important challenge in bioinformatics. Most existing methods are based on hypothesis testing, such as GSEA. These methods mainly focus on individual pathways and rank them based on their individual strengths. However, biological pathways often work together to function...
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