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Purpose Glioma is one of the lethal cancers which needs effective therapeutic target. TRIM44 has been found playing a carcinogenic role in human tumors such as breast cancer and ovarian cancer. However, the pathophysiological significance of TRIM44 in glioma is still unclear. Methods Quantitative-PCR and western blot were used to assess the expression of TRIM44 in glioma cells. For cell proliferation,...
The deubiquitinating enzyme, USP7/HAUSP (herpesvirus‐associated ubiquitin‐specific protease), is a key regulator of the tumor suppressor p53 and plays a major role in regulating genome stability. Here, we report that the protein stability of USP7 is regulated by the ubiquitin–proteasome pathway. We identified the thyroid hormone receptor interactor 12 (Trip12) as a ubiquitin E3 ligase for USP7. We...
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