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Of major interest to translational genomics is the intervention in gene regulatory networks (GRNs) to affect cell behavior; in particular, to alter pathological phenotypes. Owing to the complexity of GRNs, accurate network inference is practically challenging and GRN models often contain considerable amounts of uncertainty. Considering the cost and time required for conducting biological experiments,...
One of the main issues in systems biology is limited resources for conducting biological experiments. Therefore, a strategy for prioritizing the experiments seems to be inevitable. Experimental design is the process of planning experiments in such a way to make experiments as informative as possible. In this work, we propose a novel strategy for designing effective experiments that can optimally reduce...
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