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The involvement of μ-opioid receptors in memory retrieval was examined in mice by using Tyr-d-Arg-Phe-β-Ala-NH 2 (TAPA), a novel dermorphin analog with high affinity for μ-opioid receptors, and passive avoidance learning. TAPA was intracerebroventricularly administered to mice before retention tests of passive avoidance learning. A 0.3-ng dose of TAPA markedly shortened step-down latency...
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