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Actinohivin (AH) is a new potent anti‐HIV lectin of microbial origin. In order to modify it to produce a more efficient drug, its three‐dimensional structure has previously been determined with and without the target α(1–2)mannobiose moiety of the high‐mannose‐type glycan (HMTG) attached to HIV‐1 gp120. However, ambiguity remained in the structures owing to packing disorder that was possibly associated...
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